University of Pécs
Institute for Translational Medicine
Address: 12 Szigeti str. H-7624 Pécs, Hungary
In modern societies obesity is an important public health problem. Obesity is associated with inflammatory response and increased oxidative stress leading to vascular and metabolic dysfunction and increased morbidity and mortality. The study aims to investigate the effect of calorie restriction on different metabolic parameters and on vasomotor function in high fat diet-induced obese mice. Changes in the thermal balance (hypothermia, hyperthermia, and fever) indicate changes in energy balance, and we are able to easily monitor several energetic parameters, such as core temperature, locomotor activity and heart rate (indicating metabolic rate) in freely moving animals with biotelemetry. With a pressure myograph system, we will be able to characterize the vasomotor function of skeletal muscle arteries and little veins (flow- and agonist- induced changes) in obese mice and in previously obese mice after calorie restriction. We expect that increased vascular resistance and vascular impairment such as endothelium-dependent and -independent responses could be restored after a certain calorie restriction. The objective of the proposed research is to identify effective interventions and possible targets for drug development. This would help to avoid the widespread negative effects of different components of the very common obesity and metabolic syndrome, which impairs the quality of life and limits longevity.
DIO (diet-induced obesity) animals, measurement of metabolic rate, heat loss and core temperature, measurement of heart rate, core temperature and physical activity with biotelemetry, measuring endothelium-dependent and endothelium-independent vasomotor function with isometric myograph, data analysis.
Solymár, M., Pétervári, E., Balaskó, M. and Szelényi, Z., 2015. The onset of daily torpor is regulated by the same low body mass in lean mice and in mice with diet-induced obesity. Temperature, 2(1), pp.129-134.
Solymár, M., Szelényi, Z. and Pétervári, E., 2011. A fever-like effect of central infusion of CNTF in freely moving mice with diet-induced obesity. Journal of Molecular Neuroscience, 45(2), pp.212-215.
Solymár, M., Ivic, I., Balaskó, M., Fülöp, B.D., Tóth, G., Tamás, A., Réman, G., Koller, A. and Reglődi, D., 2018. Pituitary adenylate cyclase-activating polypeptide ameliorates vascular dysfunction induced by hyperglycaemia. Diabetes and Vascular Disease Research, p.1479164118757922.
Zsiborás, C., Mátics, R., Hegyi, P., Balaskó, M., Pétervári, E.… Solymár, M. 2018. Capsaicin and capsiate could be appropriate agents for treatment of obesity: A meta-analysis of human studies. Critical reviews in food science and nutrition, 58(9), pp.1419-1427.
Kanizsai, P., Garami, A., Solymár, M., Szolcsányi, J. and Szelényi, Z., 2009. Energetics of fasting heterothermia in TRPV1-KO and wild type mice. Physiology & behavior, 96(1), pp.149-154.
Garami, A., Balaskó, M., Székely, M., Solymár, M. and Pétervári, E., 2010. Fasting hypometabolism and refeeding hyperphagia in rats: Effects of capsaicin desensitization of the abdominal vagus. European journal of pharmacology, 644(1-3), pp.61-66.
Rostás, I., Tenk, J., Mikó, A., Füredi, N., Soos, S., Solymár, M., Lengyel, A., Székely, M., Gaszner, B., Feller, D. and Pétervári, E., 2016. Age-related changes in acute central leptin effects on energy balance are promoted by obesity. Experimental gerontology, 85, pp.118-127.