The incidence and prevalence of the disease is different for each geographical region and ethnic group, and its incidence has been increasing in recent decades. In the development of IBD, various environmental factors and host factors (genetic, epithelial, immunorechanisms and non-immunogenic factors) play a role. Its symptoms can be varied, diagnosis is based on a joint evaluation of clinical picture, laboratory, radiological, endoscopic examinations and histopathological findings. Since the exact cause of the disease is unknown, therefore, current therapeutic options are largely empirical, mainly modulating the effects of the intestinal immune system. To detect the disease on time and a proper treatment of the disease precedes the development of many complications and surgical interventions.
By analyzing the clinical data in, we can get detailed, reliable data on symptoms, complications, and extraintestinal manifestations. Multicentre, prospective data collection is aimed at investigating the so-called predictive factors affecting the epidemiology of the disease, the course of the disease and the response to the therapy. Along with the course of the disease, we are going to follow the different therapeutic methods used in the illness and any surgical interventions that may be necessary. Additionally, we will analyze some special conditions that can affect the disease (eg, pregnancy). Our aim is to investigate the genetic variants (prone genes, gene polymorphisms) associated with the development of IBD and to find genotypic and phenotypic differences in each subgroup.