Incidence of exocrine pancreatic insufficiency, nutritional deficiencies, and impaired quality of life inpatients following an attack of acute pancreatitis – PAPPEI study

International multicentre observational study

As knowledge of fluid therapy, nutrition, and critical care for organ failure has increased dramatically over the decades, the survival rate of patients with acute pancreatitis (AP) has increased dramatically and an understanding of the long-term complications of the disease is essential.
Recent studies have shown that patients with AP have a high prevalence of pancreatic exocrine insufficiency (PEI) both during initial hospitalisation and during long-term follow-up.
However, studies investigating the effect of pancreatic enzyme replacement therapy on PEI after AP are lacking.

Study Objective:
Prospective evaluation of PEI, nutritional status and quality of life during hospitalization (early admission period) and 3 months and 12 months after acute pancreatitis. The aim of this study is to clarify the incidence, natural history and duration of PEI and to identify subgroups of patients at high risk of developing PEI after AP. The results of this study will provide a basis for the design of future randomised control trials of pancreatic enzyme replacement after AP.

Local coordinator: Dr. Orsolya Eperjesi (