Coronavirus (SARS-CoV-2) Registry

On the morning of March 12, 2020, the World Health Organization (WHO) announced the outbreak of the new coronavirus disease 2019 (COVID-2019) pandemic. By the time the protocol was written, according to a summary report from Johns Hopkins University, a total of more than 4,444,670 cases had been confirmed in 188 countries and the epidemic had claimed the lives of 302,493 people. This trend predicts that the epidemic is still far from peaking. As with other infectious diseases, some cases occur asymptomatically or with mild symptoms and therefore remain undiagnosed. Thus, it is difficult to accurately estimate the true incidence and outcome of the disease. An analysis of 72,314 Chinese patients with the SARS CoV-2 epidemic found that 5% of the population required intensive care unit (ICU) treatment, with the most common indications being acute respiratory failure, septic shock, and / or multiple organ failure. Similar data were reported from Italy. Two days after the outbreak in Italy, 60% of the ICU beds in the Lombardy region had COVID-19 patients, a situation that has since deteriorated significantly. Based on Chinese data, the clinical presentation of COVID-19 shows a milder course, out of 2143 infected children, only one died and in most cases a mild course was observed, however, similar to adults, 5.9% had a critical illness requiring ICU care.The purpose of the registry and biobank is to understand the development, epidemiology, diagnosis, symptomatology, and therapy of SARS-CoV-2 infection, as well as to investigate biomarkers and map the genetic background.